Japan Drugstore Guide: Best Medicine for Constipation

Even with a healthy lifestyle, constipation can sneak up on you. If diet and exercise alone aren’t enough, there’s no need to suffer in silence.

Japanese drugstores offer a wide range of gentle, effective over-the-counter remedies that help get things moving again—without harsh side effects. Whether you’re after a natural herbal formula, a mild option for kids or seniors, or something fast-acting, there’s a product to suit every need.

While browsing the aisles, look for labels like 便秘薬 (benpiyaku – laxatives) or 整腸薬 (seicho-yaku – intestinal medicine).

Below is a roundup of pharmacist-recommended constipation relief products commonly found in Japanese pharmacies. Don’t let bloating, sluggish digestion, or irregularity slow you down—relief is just a tablet away!

Daichi No Kampo Benpiyaku (大地の漢方便秘薬) 

Summary and What Pharmacists Say: 

If you’re new to laxatives and want something gentle and natural, Earth’s Herbal Medicine for Constipation is a great place to start. Made with Daiokanzoto extract powder (a traditional blend of rhubarb root and licorice), this formula helps get things moving smoothly overnight while also easing bloating, breakouts, and other digestive-related symptoms. Pharmacists often recommend this herbal remedy for first-time users because it’s mild yet effective. Just take it before bed, and if you get a good night’s sleep, you can expect a gentle bowel movement about 8 to 10 hours later. You can even split the tablet in half by hand or with a spoon to adjust the dose as needed.

Active Ingredient: Daiokanzoto extract powder (Jinkui Yaolue, 26.7% in content) (800mg per four tablets, maximum daily dosage for 15 years or over)

Dosage: Take once a day with cold or lukewarm water before bedtime. Not suitable for under 5-year-olds.

AgeMild Constipation(2-3 days no movement)Persistent Constipation(4+ days no movement)15 years or over1-3 tablets2-4 tablets5-14 years ½ to 1½ tablets 1-2 tablets

Price: ~¥1,300 for 65 tablets (varies by pharmacy).

Magnesium Oxide E Laxative (酸化マグネシウムE便秘薬

Summary and What Pharmacists Say: 

Looking for a gentle laxative that works for the whole family? This mild, non-irritating option uses Magnesium Oxide to naturally draw water into your intestines, softening stool and making it easier to go. The subtle lemon flavor and easy-to-dissolve tablets make it simple for kids, older adults, and anyone who struggles with harsh medicines. It can also help ease related issues like bloating, poor appetite, skin troubles, and hemorrhoids. Pharmacists recommend taking it before bed or on an empty stomach with plenty of water (at least 1 to 2 glasses) to help it work better. Since everyone’s system is different, start with the minimum dose (3 tablets for adults) and adjust as needed. Expect relief in 6–12 hours. Its gentle formula makes it a go-to for pregnant women, kids over 5, and older adults alike.

Active Ingredient: Magnesium Oxide (2000mg per six tablets)

Dosage: Take once a day with cold or lukewarm water before bedtime. Start with the minimum dose and adjust as needed. Not suitable for those under 5 years old.

AgeDosage15 years or over3-6 tablets11-14 years 2-4 tablets7-10 years 2-3 tablets5-6 years 1-2 tablets

Price: ~¥1,300 for 90 tablets (varies by pharmacy).

Oil Dell (オイルデル)

Summary and What Pharmacists Say: 

If constipation is leaving you uncomfortable—especially when stool is hard and difficult to pass—this gentle laxative offers relief without harsh effects. Its key ingredient, dioctyl sodium sulfosuccinate (DSS), draws in moisture to soften hardened stool, while natural oils from powdered hemp seed (masinin) coat it so it passes more smoothly. This dual action helps your body get back to normal without the cramping or urgency that stronger laxatives can cause. It also eases constipation-related symptoms like headaches, bloating, skin troubles, and loss of appetite. Pharmacists recommend it for adults with sensitive systems or recurring constipation who want steady, gentle relief. Best suited for short-term or occasional use, with results usually seen in 6–12 hours.

Active Ingredient: Dioctyl Sodium Sulfosuccinate (200mg per eight capsules)

Dosage: Take twice daily (morning and evening) on an empty stomach with water or lukewarm water. Start with the minimum and adjust as needed. Not suitable for under 15-year-olds.

AgeDosage15 years or over3-4 capsules

Price: ~¥1,100 for 24 capsules (varies by pharmacy).

Colac (コーラック)

Summary and What Pharmacists Say:

If chronic constipation is slowing you down, Colac is a reliable option that works right where it’s needed—your intestines. These small pink pellets contain bisacodyl, a proven ingredient that directly stimulates the large intestine to get things moving. Thanks to a unique five-layer coating, the tablets bypass the stomach without dissolving too early, ensuring the medicine activates only in the intestines. Taken before bed or a few hours before you expect a bowel movement, Colac usually works within 6 to 11 hours, making it a convenient overnight solution. Pharmacists recommend it for people dealing with ongoing or habitual constipation who need effective, predictable relief. Just remember to take it on an empty stomach—not after meals—for best results.

Active Ingredient: Bisacodyl (10mg per two tablets)

Dosage: Take once a day before bedtime or a few hours before expected bowel movements. Take on an empty stomach with water or lukewarm water. Not suitable for under 15-year-olds.

AgeDosage15 years or over2 tablets

Price: ~¥1,100 for 60 tablets (varies by pharmacy).

This information is based on interviews with Japanese drugstore employees and available product data as of August 2025. Always read the product packaging and instructions carefully, and consult with a healthcare professional if you have any concerns or questions regarding treatment. 

For more information, read our full guide to drugstores in Japan.

This page has been brought to you as a public service of The Bluff Medical and Dental Clinic in Yokohama.


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